Hosted by: Doctor’s Data
Gut microbial aging, intestinal barrier dysfunction, and chronic low-grade inflammation (inflammaging) are increasingly recognized as modifiable contributors to cognitive and functional decline. This session reviews how the gut microbiome changes with age, including loss of diversity and butyrate-producing taxa, and how these shifts weaken the mucosal barrier and increase zonulin and LPS translocation. It then follows the resulting inflammatory signal to the brain, where blood-brain barrier changes and neuroinflammation affect the hippocampus. Attendees will learn which objective measures are available today (stool microbiome diversity and dysbiosis profiles, zonulin, hs-CRP) and how to incorporate these into practice. They will also learn how to apply evidence-based dietary, nutraceutical, and medication-review strategies in a rational sequence, with dosing limits and reassessment.
What you will learn
By the end of this session you will be able to:
- Describe age-associated changes in gut microbiome composition and diversity, including loss of butyrate producers, and how they relate to biological age.
- Explain how intestinal barrier dysfunction, zonulin, and LPS translocation contribute to inflammaging, neuroinflammation, and cognitive decline.
- Interpret stool microbiome diversity and dysbiosis profiles, zonulin, and hs-CRP in a patient with cognitive or functional decline and recognize the limits of these tests.
- Apply evidence-based dietary, nutraceutical, and medication-review strategies to restore microbial diversity and barrier integrity, including sequencing, dosing limits, and reassessment.
Presenter
| Wednesday, November 4, 2026 at 12 PM Pacific Live webinar presented by Julia Malkowski, ND, DC |
References to webinars are from our accredited laboratory network. Health care providers are encouraged to explore the original source material and apply their clinical expertise when interpreting this information.