Explore available Lyme disease testing options and access the information you need to determine the most appropriate testing approach for your patients.
Tickplex Basic – The TickPlex® Basic assay detects and quantitates IgM- and IgG-class antibodies against Borrelia afzelii, Borrelia burgdorferi, and Borrelia garinii including persistent (“round body”) forms. Specificity is improved by detecting pleomorphic forms of Borrelia.
Tickplex Plus – The TickPlex® Plus assay detects and quantifies IgM- and IgG-class antibodies against Borrelia afzelii, Borrelia burgdorferi, and Borrelia garinii, including persistent (“round body”) forms. The panel also assesses antibody responses to multiple tick-borne co-infections and associated pathogens. Please note this test is not orderable for Ontario ND’s.
Borrelia IgG or IgM SeraSpot – Serological Tests are blood-based antibody assays that utilize SeraSpot®, ELISA, IFT, Immunoblot, and Immunoarray technologies to evaluate immune responses to Lyme disease, tick-borne co-infections, viral infections, and other bacterial, parasitic, and fungal pathogens.
Lyme Immunoblot Panel 1 – The panel includes Lyme screening immunoassays together with Lyme ImmunoBlot IgM and IgG assays, providing information on antibody responses associated with early, active, or later-stage infection. The ImmunoBlot methodology utilizes recombinant Borrelia antigens and is designed to evaluate antibody reactivity to multiple Lyme-associated species and strains.
Lyme Disease Antibody Immunoblot – The Lyme Disease Antibody Immunoblot is a serum-based IgG and IgM antibody assay that evaluates immune responses to multiple Borrelia burgdorferi antigens using protein microarray immunoblot technology. The test assesses antibody reactivity to Lyme disease-associated proteins and provides both qualitative immunoblot results and antigen-specific band detection.
Did You Know?
While Lyme disease is caused by Borrelia bacteria, ticks can carry more than one microorganism. In some cases, a person may be exposed to additional bacteria, parasites or other infectious agents from the same tick bite. These are commonly referred to as co-infections.*
Because symptoms such as fatigue, headaches, cognitive difficulties, and muscle or joint discomfort can be associated with a variety of conditions, some health-care providers may consider additional testing based on a patient’s history, symptoms and overall presentation. Depending on the situation, additional assessments may include evaluation for other tick-borne infections, viral markers such as Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpesvirus 6 (HHV-6), as well as other immune-related factors that may contribute to similar symptoms.**
Sources
* Cameron DJ, Johnson LB, Maloney EL. Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease. Expert Review of Anti-infective Therapy. 2014;12(9):1103-1135. Published on behalf of the International Lyme and Associated Diseases Society (ILADS). The guideline discusses the potential for exposure to multiple tick-borne pathogens and the importance of considering associated tick-borne infections when clinically appropriate.
** Shikova E, Reshkova V, Kumanova A, et al. Cytomegalovirus, Epstein-Barr virus, and human herpesvirus-6 infections in patients with myalgic encephalomyelitis/chronic fatigue syndrome. Journal of Medical Virology. 2020;92(12):3682-3688. This study discusses EBV, CMV and HHV-6 as infections that have been associated with symptoms such as fatigue, cognitive difficulties and musculoskeletal discomfort, which may overlap with those seen in a variety of other conditions.
Please note: Our test catalogue may not include all available Lyme disease testing options. If you do not see a specific test listed, please contact us for information on additional testing solutions.